反应详情

温度

100 °C

To a mixture of 2-[2-(3-fluoro-phenyl)-ethylamino]-thiazol-4-one (38.1 mg, 0.16 mmol) (see Example 7), AcONa (160 mg, 1.95 mmol), and 8-isopropoxy-[1,5]naphthyridine-2-carbaldehyde (38.9 mg, 0.18 mmol) (see Example 20) in a sealed tube was added AcOH (0.3 mL). The reaction mixture was heated to 100° C. (oil bath) for 4 hrs. The reaction mixture was then cooled to r.t. and triturated with water. The solid was collected by filtration and washed with water, acetone and ether to give 2-[2-(3-fluoro-phenyl)-ethylamino]-5-(8-isopropoxy-[1,5]naphthyridin-2-ylmethylene)-thiazol-4-one as a light green solid (45.9 mg, 65.8%). HR-ES (+) m/e calcd for C23H21FN4O2S (M+H)+ 437.1442. found 437.1443.

1. temperatureThe reaction mixture was then cooled to r.t.
2. customtriturated with water
3. filtrationThe solid was collected by filtration
4. washwashed with water, acetone and ether