反应详情

The product of Step d (0.4 g) dissolved in MeOH (6 ml) was added to cyclopropanecarbaldehyde (0.116 ml) and the resulting mixture was stirred for 4 hours. The solvent was evaporated, the residue re-dissolved in methanol (6 ml) and NaBH4 (0.095 g) added and the mixture left for 30 minutes. Aqueous sodium hydroxide (1N) was added and the aqueous extracted with diethyl ether. The organic extracts were dried with Na2SO4, filtered and concentrated to give the sub-title product as an oil (0.493 g).

1. customThe solvent was evaporated
2. dissolutionthe residue re-dissolved in methanol (6 ml)
3. additionNaBH4 (0.095 g) added
4. waitthe mixture left for 30 minutes
5. additionAqueous sodium hydroxide (1N) was added
6. extractionthe aqueous extracted with diethyl ether
7. dry with materialThe organic extracts were dried with Na2SO4
8. filtrationfiltered
9. concentrationconcentrated