Sodium Hydroxide → HCID 69311930, compound

HRID 968763Notes

Reaction equation

HRID 968763 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:22]=[CH:23][C:24]=1[F:25])[O:5][CH:6]1[CH2:11][CH2:10][N:9]([CH2:12][CH2:13][N:14](C)[C:15](=O)C(F)(F)F)[CH2:8][CH2:7]1.[OH-].[Na+]>C(O)C>[F:1][C:2]1[CH:3]=[C:4]([CH:22]=[CH:23][C:24]=1[F:25])[O:5][CH:6]1[CH2:7][CH2:8][N:9]([CH2:12][CH2:13][NH:14][CH3:15])[CH2:10][CH2:11]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86760586HCID 86760586, compound

Product 1

HCID 69311930HCID 69311930, compoundYield 90.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of the product of Step b (0.3 g) in ethanol (15 ml) was added a 2M solution of sodium hydroxide (5 ml). The mixture was stirred at RT for 72 hours. The resultant mixture was partitioned between EtOAc (20 ml) and water (20 ml). The organic layer was separated and dried with MgSO4. Removal of solvent under reduced pressure gave the title compound (0.2 g).

Workup

  1. customThe resultant mixture was partitioned between EtOAc (20 ml) and water (20 ml)
  2. customThe organic layer was separated
  3. dry with materialdried with MgSO4
  4. customRemoval of solvent under reduced pressure

Sources & evidence

ORD record
ord-1a4337a55bbc44dd8c4b8f01882d2f37
Source dataset
uspto-grants-2007_12
Patent number
US07304077B2

Reaction notes

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