Triethylamine → HCID 69521992, compound

Participants

Reaction Steps

To a solution of the product of Step c (0.145 g) and triethylamine (0.224 ml) in THF (3 ml) at 0° C. was added a solution 3-methoxybenzoyl chloride (0.083 ml) in THF (2 ml). The mixture was stirred for 1 hour then partitioned between ethyl acetate and water. The organic layer was separated and dried with MgSO4 and the solvent removed by evaporation. Purification by reverse phase HPLC (with a gradient eluent system 25% MeCN/NH4OAc(aq) (0.1%) to 95% MeCN//NH4OAc(aq) (0.1%)) evaporation of solvent and the residue was dissolved in diethyl ether and HCl (1 ml 1M solution in diethyl ether) added. Filtration gave the title compound (0.137 g).

Provenance & Evidence