HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → HCID 18930691, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Methyl 3-Hydroxybenzoate | HCID 88068 | — |
| Reactant | tert-Butyl N-(2-bromoethyl)carbamate | HCID 4103526 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 18930691 | HCID 18930691 | 45.5% |
Reaction Steps
To a solution of tert-butyl 2-bromoethylcarbamate (5 g) and methyl 3-hydroxybenzoate (3.4 g) in dimethylformamide (60 ml) was added caesium carbonate (14.5 g) and the reaction stirred for 12 hours before partitioning between water and ethyl acetate. The organic layer was separated, dried with MgSO4 and the solvent removed by evaporation. Purification by flash chromatography (ethyl acetate:isohexane 92.5:7.5) gave the sub-title product as a colourless oil (3 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07304077B2 |
| Source dataset | uspto-grants-2007_12 |
| ORD ID | ord-3ad07ba5b2b64bd0b34120d21fd4e6e6 |
| Source note | uspto-grants-2007_12 |