Borane → HCID 69523344, compound

Participants

Reaction Conditions

Reaction Steps

The product from Example 20, step b) (0.544 g) was dissolved in THF (5 ml) and borane [10.05 ml (1M in THF)] was added. The reaction was heated at reflux for 2 hours. The reaction was quenched slowly with MeOH and the solvents evaporated. Aqueous HCl (5 ml Concentrated HCl: 5 ml H2O) was added and the reaction heated at 70° C. for 1 hour. NaOH (2M) was added until pH 9 was reached. The product was extracted with CH2Cl2 and the combined organics washed with saturated aqueous NaHCO3, dried with Na2SO4 and solvents evaporated. Purification by flash chromatography (dichloromethane:methanol: 880 NH3 (aq) 89:10:1)gave the sub-title compound as an oil (0.377 g).

Provenance & Evidence