反应详情

As to General Reaction Scheme 3, intermediate (22) (produced via, inter alia, General Scheme 2) is nitrated by a nitrating agent to yield intermediate 7-Methyl-6-nitro-1H-benzimidazole-4-carboxylic acid (23). In turn, intermediate (23) may either be amidated/dehydrated by an amidating/dehydrating agent to yield intermediate 7-Methyl-6-nitro-1H-benzimidazole-4-carbonitrile (24), or amidated by an amidating agent to yield intermediate 7-Methyl-6-nitro-1H-benzimidazole-4-carboxamide (25). Intermediate (24) is reduced by a nitro group reducing agent to yield intermediate (10). In turn, intermediate (25) is reduced by a nitro group reducing agent to yield intermediate 6-Amino-7-methyl-1H-benzimidazole-4-carboxamide, hydrochloric acid salt (26), and thereafter dehydrated by an amide dehydrating agent to yield intermediate (10). See Examples 13 and 14.