Sulfuric Acid → 3-Amino-4-methyl-2-nitrobenzoic acid

Participants

Reaction Conditions

Reaction Steps

To a 70% aqueous solution of H2SO4 (100 mL) is added 3-(Acetylamino)-4-methyl-2-nitrobenzoic Acid (15) (14.30 g, 60.00 mmol), and the reaction mixture heated to about 115° C. for about 30 minutes. The mixture is then cooled to ambient temperature, added to ice water (250 mL) and held at about 0° C. for about 30 minutes. The resulting solid is filtered, washed with water (100 mL), and dried to provide 3-amino-4-methyl-2-nitrobenzoic acid (16) as a rust colored solid (7.17 g, 61% yield).

Provenance & Evidence