Formic Acid → HCID 59016304, compound

HRID 968795Notes

Reaction equation

HRID 968795 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[CH3:11])[C:5]([OH:7])=[O:6].[CH:12](O)=[O:13]>>[CH:12]([NH:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[CH3:11])[C:5]([OH:7])=[O:6])=[O:13]

Participants

3

Reactant 2

HCID 284Formic AcidHCID 755683-Amino-4-methylbenzoic acid

Product 1

HCID 59016304HCID 59016304, compound

Procedure

A mixture of 3-amino-4-methylbenzoic acid (13) (22.139 g, 146.5 mmol) and 90% aqueous formic acid (200 mL) is heated at reflux for about 2 hours. The mixture is cooled to ambient temperature, added to ice water (400 mL) and stirred for about 15 minutes. The solids obtained are filtered and dried to obtain 3-(formylamino)-4-methylbenzoic acid (17), as a light flaky purple-pink solid (23.213 g, 88% yield).

Workup

  1. temperatureis heated
  2. temperatureat reflux for about 2 hours
  3. customThe solids obtained
  4. filtrationare filtered
  5. customdried

Sources & evidence

ORD record
ord-2c7061783f7a4e77a8886beb0d515f9d
Source dataset
uspto-grants-2007_12
Patent number
US07304084B2

Reaction notes

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