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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 9688Generated: October 25, 2026

1-(4-Methoxyphenyl)piperazine → {2-{[4-(4-Methoxyphenyl)piperazin-1-yl]methyl}-5-[4-(trifluoromethyl)phenyl]-3-furyl}methanol

https://huagongshe.com/reaction/9688

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(4-Methoxyphenyl)piperazineHCID 269722—
ReactantMethyl 2-bromomethyl-5-[4-(trifluoromethyl)phenyl]-3-furoateHCID 21986318—
Product{2-{[4-(4-Methoxyphenyl)piperazin-1-yl]methyl}-5-[4-(trifluoromethyl)phenyl]-3-furyl}methanolHCID 21986539—

Reaction Steps

The title compound was prepared using methyl 2-(bromomethyl)-5-[4-(trifluoromethyl)phenyl]-3-furoate (intermediate 44) and 1-(4-methoxyphenyl)piperazine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07091237B2
Source datasetuspto-grants-2006_08
ORD IDord-b4b250cb2381419385197056ebaf170b
Source noteuspto-grants-2006_08