反应详情

A mixture of 3-Amino-6-bromo-4-methylbenzoic Acid (19) (6.4145 g, 27.88 mmol) in 90% aqueous formic acid (36 mL) is heated to reflux for about 3 hours. The mixture is then cooled to ambient temperature, added to ice water (150 mL) and stirred for about 15 minutes. The solids that form are filtered and dried to provide 3-(Formylamino)-6-bromo-4-methylbenzoic Acid (20):, as a purple-pink solid (5.961 g, 82% Yield).

1. temperatureis heated
2. temperatureto reflux for about 3 hours
3. filtrationThe solids that form are filtered
4. customdried