Ethyl Acetate → HCID 22930226, compound

Participants

Reaction Steps

A solution of 2-nitro-1H-imidazole potassium salt (300 mg, 2.0 mmol), 3-ethylpentyl methanesulfonate (463 mg, 2.4 mmol) and 18-crown-6 (1.1 g, 4.2 mmol) in acetonitrile (10 ml) was heated at 80° C. for 6 hours. After cooling to room temperature, ethyl acetate and water were added and the organic layer was separated off. After washing with water and brine, drying was performed with anhydrous sodium sulfate and the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography (solvent: n-hexane-ethyl acetate) to yield the title compound (370 mg) as a colorless oil.

Provenance & Evidence