HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl 4-bromo-3-methylbenzoate → Tert-butyl 3-methylbenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl 4-bromo-3-methylbenzoate | HCID 11845988 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethylacetate methanol | HCID 21584119 | — |
| Product | Tert-butyl 3-methylbenzoate | HCID 236097 | 97% |
Reaction Steps
4-Bromo-3-methyl-benzoic acid tert-butyl ester (0.39 g, 1.438 mmol) was hydrogenated over 10% Pd—C (0.5 g) under H2 (50 psi) in EtOAc—MeOH (4:1, 20 mL) for 5 h. After filtration through Celite, filtrate was evaporated to dryness. Yield: 97%. MS (ESI) 193.28 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07304085B2 |
| Source dataset | uspto-grants-2007_12 |
| ORD ID | ord-f327d32dbfcf40f8b6a78ba329312724 |
| Source note | uspto-grants-2007_12 |