HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 2-Dimethylaminopyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Succinic anhydride | HCID 7922 | — |
| Reactant | Maleic Anhydride | HCID 7923 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Solvent | Toluene | HCID 1140 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-Dimethylaminopyridine | HCID 21885 | — |
Reaction Steps
For the production of compound (1) wherein R5 is RB, for example, as shown by the following formulas, compound (1-1) obtained in Step 3A is reacted with acid anhydride such as acetic anhydride, succinic anhydride, maleic anhydride and the like or acyl halide in chloroform, methylene chloride, tetrahydrofuran, toluene, ethyl acetate and the like or a mixed solvent thereof, in the presence of a base such as pyridine, triethylamine, dimethylaminopyridine and the like, whereby compound (1-8) can be obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07304174B2 |
| Source dataset | uspto-grants-2007_12 |
| ORD ID | ord-d9defc93a7fd42fa9047fab8f71fa76c |
| Source note | uspto-grants-2007_12 |