Sulfuric Acid → HCID 23109632, compound

Participants

Reaction Steps

1-(3-Fluoro-4-methylphenyl)-2-methylpropan-2-ol (130.1 g) obtained in Step 5 was dissolved in chloroacetonitrile (139 ml) and acetic acid (115 ml), and concentrated sulfuric acid (33.4 ml) was added dropwise under ice-cooling. The mixture was stirred at room temperature for 2 hrs and 4N-aqueous sodium hydroxide solution (16 ml) was added dropwise under ice-cooling. The mixture was extracted twice with toluene and twice with ethyl acetate. The organic layer was washed twice with 10% brine and concentrated under reduced pressure to give the title compound (131.6 g).

Provenance & Evidence