Methanol → Methyl (3-fluoro-4-methylphenyl)acetate

Participants

Reaction Conditions

Reaction Steps

(3-Fluoro-4-methylphenyl)acetic acid (105.3 g) was dissolved in methanol (740 ml). Concentrated sulfuric acid (9.9 ml) was added and the mixture was stirred at 85° C. for 1 hr. The reaction mixture was allowed to return to room temperature, and concentrated under reduced pressure. Water was added to the obtained residue and the mixture was extracted with ethyl acetate (1 L). The organic layer was washed successively with water, saturated aqueous sodium hydrogencarbonate solution, water and brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give the title compound (114.2 g).

Provenance & Evidence