Sodium borohydride → HCID 23109584, compound

Participants

Reaction Steps

Methyl 4-(2-acetylphenoxy)-3-methoxybenzoate (1.24 g) obtained in Step 1 was dissolved in methanol (20 ml), and after ice-cooling, sodium borohydride (312 mg) was added. The mixture was stirred for 2 hrs. The reaction mixture was concentrated under reduced pressure, and water was added. The mixture was extracted with ethyl acetate. The organic layer was washed successively with 5% aqueous citric acid solution and brine, and dried over sodium sulfate. The obtained residue was purified by silica gel column chromatography (hexane:ethyl acetate=3:1) to give the title compound (834 mg).

Provenance & Evidence