HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 969086Generated: October 31, 2026
Pyrrolidine → Ethyl 1-(6-pyrrolidin-1-ylpyridin-3-yl)cyclopropanecarboxylate
https://huagongshe.com/reaction/969086
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | Ethyl 1-(6-chloropyridin-3-yl)cyclopropanecarboxylate | HCID 86602273 | — |
| Product | Ethyl 1-(6-pyrrolidin-1-ylpyridin-3-yl)cyclopropanecarboxylate | HCID 66661814 | — |
Reaction Steps
A mixture of ethyl 1-(6-chloropyridin-3-yl)cyclopropanecarboxylate (69.8 mg, 0.309 mmol) and pyrrolidine (250.0 μL, 3.0 mmol) in a sealed tube was heated at 100° C. for 4 hours. Then the excess pyrrolidine in the mixture was removed under reduced pressure. The residue was purified by flash chromatography column to afford ethyl 1-(6-pyrrolidin-1-ylpyridin-3-yl)cyclopropanecarboxylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07304081B2 |
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| Source dataset | uspto-grants-2007_12 |
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| ORD ID | ord-6e795fbd5810404ea9dc2acf86dd4d72 |
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| Source note | uspto-grants-2007_12 |
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