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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 969120Generated: November 1, 2026

Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate → 1-[6-(Benzyloxy)pyridin-3-yl]cyclopropanecarboxylic acid

https://huagongshe.com/reaction/969120

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphateHCID 151348—
Reactant(1r)-1'-({1-[6-(Benzyloxy)pyridin-3-yl]cyclopropyl}carbonyl)-3h-spiro[2-benzofuran-1,3'-pyrrolidin]-3-oneHCID 66662157—
Product1-[6-(Benzyloxy)pyridin-3-yl]cyclopropanecarboxylic acidHCID 66661660—

Reaction Steps

Following the BOP coupling the desired product, (1R)-1′-({1-[6-(benzyloxy)pyridin-3-yl]cyclopropyl}carbonyl)-3H-spiro[2-benzofuran-1,3′-pyrrolidin]-3-one, was purified by prep-HPLC. LC/MS: 441.2 (M+H+).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07304081B2
Source datasetuspto-grants-2007_12
ORD IDord-bd7c67851cb745669275abb961721f8b
Source noteuspto-grants-2007_12