HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 1-[4-(Pyrrolidin-1-ylmethyl)phenyl]cyclopropanecarboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1-[4-(Pyrrolidin-1-ylmethyl)phenyl]cyclopropanecarbonitrile | HCID 66662363 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-[4-(Pyrrolidin-1-ylmethyl)phenyl]cyclopropanecarboxylic acid | HCID 66661853 | — |
Reaction Steps
A solution of 1-[4-(pyrrolidin-1-ylmethyl)phenyl]cyclopropanecarbonitrile (100 mg, 0.0004 mol) in ethanol (5 mL, 0.08 mol) and 50% NaOH (aq. 4 ml) and water (2 ml) was stirred at 100 celsius overnight. The mixture was then carefully adjusted to be slightly acidic (pH=6) and the precipitate formed was filtered and dried to afford the product. LC-MS: 246.1 (M+H)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07304081B2 |
| Source dataset | uspto-grants-2007_12 |
| ORD ID | ord-2ad74dea1ce84dd7941f7d9225786205 |
| Source note | uspto-grants-2007_12 |