Methanol → HCID 66661927, compound

HRID 969195Notes

Reaction equation

HRID 969195 reaction equation
C([N:8]1[CH2:12][CH:11]([CH2:13][OH:14])[CH:10]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[OH:21])[CH2:9]1)C1C=CC=CC=1.CO>[Pd]>[OH:14][CH2:13][C@H:11]1[CH2:12][NH:8][CH2:9][C@H:10]1[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[OH:21]

Participants

4

Reactant 2

HCID 887MethanolHCID 19694419HCID 19694419, compound

Product 1

HCID 66661927HCID 66661927, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

A mixture of 2-[1-benzyl-4-(hydroxymethyl)pyrrolidin-3-yl]phenol (101.4 mg, 0.0003580 mol) and palladium (10% on carbon, 75 mg) in methanol (5.0 mL, 0.12 mol) was stirred under hydrogen (balloon) overnight. The mixture was filtered and the filtrate was concentrated. The residue was used in next step without further purification.

Workup

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate was concentrated
  3. customThe residue was used in next step without further purification

Sources & evidence

ORD record
ord-e7d5a8bcf9234caa8431bdd62bba2ddb
Source dataset
uspto-grants-2007_12
Patent number
US07304081B2

Reaction notes

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