N-methyl-2-pyrrolidone → HCID 86594941, compound

Participants

Reaction Conditions

Reaction Steps

A solution of [4-chloro-5-(2-chloro-ethyl)-pyrimidin-2-yl]-(2,4,6-trimethyl-phenyl)-amine (1.3 g, 4.1 mmol) in N-methylpyrrolidinone (15 mL) was treated with 1-propyl-butylamine (1.6 g, 14 mmol) and heated to 120° C. in a sealed tube for 18 hours. Additional 1-ethyl-butylamine (0.76 g, 6.6 mmol) was added, and heating at 120° C. was resumed for 32 hours. The reaction mixture was concentrated under reduced pressure and the resulting orange solid was partitioned between ethyl acetate (100 mL) and water (100 mL). The aqueous layer was further extracted with ethyl acetate (2×75 mL), and the combined extracts were washed with 15% aqueous sodium hydroxide (2×50 mL) and brine (30 mL), dried over magnesium sulfate, filtered, and concentrated under reduced pressure. The crude brown oil was chromatographed over silica gel, eluting with a gradient of 1 to 15% methanol in dichloromethane, to provide VII as an off-white solid (0.64 g, 41%; ESIMS m/z (M+H)=367).

Provenance & Evidence