反应详情

18 mL fuming nitric acid are added dropwise to a solution of 81.5 g (0.34 mol) 1-(5-benzyloxy-2-hydroxy-phenyl)-ethanone (known from U.S. Pat. No. 4,460,581) in 700 mL acetic acid while being cooled with the ice bath such that the temperature does not exceed 20° C. Then the reaction mixture is stirred for two hours at ambient temperature, poured onto ice water and filtered. The product is recrystallised from isopropanol, suction filtered and washed with isopropanol and diisopropylether. Yield: 69.6 g (72%); mass spectroscopy [M+H]+=288.

1. customdoes not exceed 20° C
2. additionpoured onto ice water
3. filtrationfiltered
4. customThe product is recrystallised from isopropanol, suction
5. filtrationfiltered
6. washwashed with isopropanol and diisopropylether