HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 3-(2-acetyl-4-benzyloxy-6-nitrophenyl)acrylate → 5-acetyl-7-benzyloxy-3,4-dihydro-1H-quinolin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 3-(2-acetyl-4-benzyloxy-6-nitrophenyl)acrylate | HCID 66751245 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-acetyl-7-benzyloxy-3,4-dihydro-1H-quinolin-2-one | HCID 21072850 | — |
Reaction Steps
5.0 g (14.07 mmol) methyl 3-(2-acetyl-4-benzyloxy-6-nitro-phenyl)-acrylate are combined with 100 mL ethanol and hydrogenated with Raney nickel as catalyst at 4 bar. The catalyst is separated off and the filtrate is acidified with 15 mL 2 N hydrochloric acid. The product that crystallises out is suction filtered and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07307076B2 |
| Source dataset | uspto-grants-2007_12 |
| ORD ID | ord-a9f1ced2c71340fd950e6d46f15755f3 |
| Source note | uspto-grants-2007_12 |