HCID 69459677, compound → HCID 69459918, compound

Participants

Reaction Steps

A solution of 220 mg (0.5 mmol) 8-benzyloxy-5-{2-[2-(2,4-difluoro-phenyl)-1,1-dimethyl-ethylamino]-1-hydroxy-ethyl}-1H-quinolin-2-one in 10 mL methanol is hydrogenated in the presence of palladium on charcoal at ambient temperature and normal pressure. Then the catalyst is separated off, the filtrate is evaporated down and the residue is chromatographed (reverse phase; water/acetonitrile gradient).

Provenance & Evidence