Water → HCID 86607441, compound

Participants

Reaction Steps

To a solution of 0.3 g (0.93 mmol) 2,3-dimethyl-8-phenyl-3,6,7,8-tetrahydro-chromeno[7,8-d]imidazole-5-carboxylic acid and 0.3 g (0.93 mmol) O(1H-benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoro-borate (TBTU) in dimethylformamide (5 ml) were added 240 μl (1.9 mmol) triethylamine and 71 μl (0.93 mmol) 3-amino-propane-1,2-diol and the suspension was stirred overnight at room temperature. The reaction was poured into water, the precipitate filtered off and purified by column chromatography on silica gel (dichloromethane/methanol=8:1) to afford 100 mg (270%) of the title compound as a white solid.

Provenance & Evidence