Phosphoric Acid → HCID 69134419, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 5 ml phosphoric acid (85%) and 260 mg (0.9 mmol) 1,2-dimethyl-5-(3phenyl-allyl)-1H-benzimidazol-4-ol was heated at 90° C. for 90 min. After cooling to room temperature, the reaction mixture was poured into water (400 ml), neutralized with 6N sodium hydroxide solution and extracted with dichloromethane (4×300 ml). The organic layers were dried over magnesium sulphate and concentrated in vacuo. The residue was purified by column chromatography on silica gel (toluene/dioxane=2:1) to afford 24.5 mg (10%) of the title compound as a white solid. m. p. 161°-164° C.

Provenance & Evidence