Sodium Hydroxide → HCID 69134440, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 2.0 g (5.6 mmol) 6-bromo-1,2-dimethyl-5-(3-phenyl-allyl)-1H-benzimidazol-4-ylamine in 10 ml phosphoric acid (85%) was heated to 130° C. for 20 min. The solution was poured onto crushed ice and the pH adjusted to pH=9 by the addition of 6N sodium hydroxide solution. The mixture was extracted with dichloromethane/methanol (10:1), the organic phase was separated, dried over anhydrous magnesium sulphate and evaporated. The residue was purified by column chromatography on silica gel (toluene/dioxane/methanol=6:3.8:02). Crystallization from diisopropyl ether yielded 1.7 g (84%) of the title compound as a colourless solid. m.p. 206-210° C.

Provenance & Evidence