Acetic Acid → HCID 69134399, compound

Participants

Reaction Steps

A solution of 9.0 g (23.8 mmol) 7-benzyloxy-3-methyl-2-trifluoromethyl-3H-benzimidazole-5-carboxylic acid dimethylamide and 1.2 ml acetic acid in 300 ml ethanol-tetrahydrofuran (1:1) was hydrogenated over 1.1 g 10% Pd/C in autoclave (5 bar H2) at 50° C. for 16 h. The catalyst was filtered off and the filtrate concentrated in vacuo to afford 6.9 g (100%) of the title compound as a white solid.

Provenance & Evidence