Carbon Dioxide → HCID 69135057, compound

Participants

Reaction Steps

15.8 g (41.0 mmol) 4-Benzyloxy-6-bromo-1-methyl-2-trifluoromethyl-1H-benzimidazole, 6.4 g (24.6 mmol) triphenylphosphine, 1.4 g (6.2 mmol) palladium(II) acetate and 205 ml (410 mmol) dimethylamine (2 M in THF) were transferred to an autoclave and carbonylated (6 bar CO2) at 120° C. for 16 h. The catalyst was filtered off and the filtrate was concentrated in vacuo. Purification of the residue by column chromatography on silica gel (dichloromethane/methanol=50:1) afforded 9.3 g (62%) of the title compound as a white solid. m.p. 144°-146° C.

Provenance & Evidence