Carbon Dioxide → HCID 69136056, compound

Participants

Reaction Steps

10.6 g (29.3 mmol) 4-Benzyloxy-bromo-1-methoxymethyl-2-methyl-1H-benzimidazole, 4.6 g (17.6 mmol) triphenylphosphine, 1.0 g (4.3 mmol) palladium(II) acetate, 148 ml (293 mmol) dimethylamine (2 M in THF) in 50 ml tetrahydrofuran were transferred to an autoclave and carbonylated (6 bar CO2) at 120° C. for 16 h. The catalyst was filtered off and the filtrate was concentrated in vacuo. The purification of the residue by column chromatography on silica gel (dichloromethane/methanol=20:1) afforded 4.9 g (50%) of the title compound as a yellow oil.

Provenance & Evidence