Sulfamide → 4-(3,4-Dichlorophenoxy)-[1,4'-bipiperidine]-1'-sulfonamide

Participants

Role	Name	HCID	Charge
Reactant	Sulfamide	HCID 82267	—
Reactant	4-(3,4-Dichloro-phenoxy)-[1,4']bipiperidine	HCID 22397434	—
Solvent	1,4-Dioxane	HCID 31275	—
Product	4-(3,4-Dichlorophenoxy)-[1,4'-bipiperidine]-1'-sulfonamide	HCID 23102762	80.6%

Reaction Steps

4-(3,4-Dichlorophenoxy)-1,4′-bipiperidine (5 g, 0.0152 mol) and sulfamide (1.45 g, 0.0152 mol) were stirred together in dioxan (150 ml) at reflux for 24 hours. The resulting mixture was cooled to ambient temperature, evaporated to dryness and the residue was triturated with ether to give the title compound as a tan solid (5 g; MS APCI 409/411 (M+H)).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07307090B2
Source dataset	uspto-grants-2007_12
ORD ID	ord-d4eb8159bf6f4990b3a63ba470156b55
Source note	uspto-grants-2007_12