tert-Butanol → HCID 86595132, compound

Participants

Reaction Conditions

Reaction Steps

tert-Butanol (0.48 ml) in dichloromethane (2 ml) was added to a solution of chlorosulfonylisocyanate (0.43 ml) in dichloromethane (5 ml) stirring at 0° C. The resulting solution was then added to a solution of 4-(3,4-dichlorophenoxy)-1,4′-bipiperidine (1.6 g) and triethylamine (0.77 ml) in dichloromethane (20 ml) at 0° C. After stirring at 0° C. for 2 h, the reaction mixture was washed with 0.1M hydrochloric acid (30 ml), dried (MgSO4) and evaporated. The residue was triturated with diethylether (20 ml) to give the title compound as a white solid. (1.9 g)

Provenance & Evidence