反应详情

To a slurry of 60% NaH suspension in DMF (30 mL) at RT added a solution of 5-nitro-2-pentafluoroethyl-phenol (3.6 g) in 5 mL DMF. The dark red mixture was stirred at RT for 10 min then added a solution of 1-Boc-4-methylsulfonyloxymethyl-piperidine (3.1 g) in 5 mL DMF. The reaction was stirred at 60° C. and 95° C. After 1 h, added 2.94 g K2CO3 and stirred overnight at 105° C. After cooling to RT, the reaction was diluted with hexanes and 1N NaOH. Separated layers, and washed organic layer with 1 N NaOH and with brine, dried over Na2SO4, filtered and concentrated in vacuo. Purification with silica gel column chromatography with 8% EtOAc/Hexanes yielded 1-Boc-4-(3-nitro-6-pentafluoroethyl-phenoxymethyl)-piperidine as a light yellow thick oil.

1. stirringThe reaction was stirred at 60° C. and 95° C
2. waitAfter 1 h
3. stirringstirred overnight at 105° C
4. temperatureAfter cooling to RT
5. washSeparated layers, and washed organic layer with 1 N NaOH
6. dry with materialwith brine, dried over Na2SO4
7. filtrationfiltered
8. concentrationconcentrated in vacuo
9. customPurification with silica gel column chromatography with 8% EtOAc/Hexanes