Diisopropylethylamine → HCID 69510757, compound

Participants

Reaction Steps

N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-nitro-benzamide (Example 7, Step A)(300 mg, 0.96 mmol) was treated with 4-methyl-piperazine-1-carbonyl chloride (200 mg, 1 mmol) in the presence of DIEA (40 mL) in THF overnight at 65° C. The mixture was partitioned between EtOAc and saturated aqueous NaHCO3. The organic layer was washed with H2O and brine, then dried over Na2SO4. The organic solution was concentrated in vacuo to yield the desired compound.

Provenance & Evidence