反应详情

To a solution of 7-{2-[1-(2-amino-pyrimidin-4-yl)-ethylamino]-benzoylamino}-4,4-dimethyl-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester (Example 125) (80 mg, 0.154 mmol) in CH2Cl2 (3 mL) was added TFA (2 mL). The resulting mixture was stirred at RT for 18 h and basified with 5 N NaOH and extracted with CH2Cl2 (2×15 mL). The combined organic layers were washed with saturated NaHCO3, water, brine, dried over MgSO4, and evaporated in vacuo to give the product. MS m/z: 417.5 (M+H). Calc'd. for C24H29N6O-417.51.

1. extractionextracted with CH2Cl2 (2×15 mL)
2. washThe combined organic layers were washed with saturated NaHCO3, water, brine
3. dry with materialdried over MgSO4
4. customevaporated in vacuo
5. customto give the product