Isoamyl Nitrite → 2-Bromo-6-chloro-9H-purine

Participants

Role	Name	HCID	Charge
Reactant	Isoamyl Nitrite	HCID 8053	—
Reactant	Bromotrimethylsilane	HCID 76113	—
Reactant	HCID 10149094	HCID 10149094	—
Solvent	Tetrahydrofuran	HCID 8028	—
Product	2-Bromo-6-chloro-9H-purine	HCID 5287744	—

Reaction Conditions

Temperature	22.5 °C

Reaction Steps

9-Acetyl-2-amino-6-chloropurine (1.00 g, 4.72 mmol), bromotrimethylsilane (2.17 g, 14.2 mmol) and isoamyl nitrite (0.83 g, 5.67 mmol) were added to tetrahydrofuran (5 ml), and the mixture was stirred at 20-25° C. for 19 hr to give 2-bromo-6-chloropurine.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07307167B2
Source dataset	uspto-grants-2007_12
ORD ID	ord-0410778b602b4fbe90a453dbb79abae1
Source note	uspto-grants-2007_12