Hydrochloric Acid → 6-n-Propyl-2-trifluoromethylimidazo[1,2-b]pyridazin-3-ylsulfonamide

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Reaction Conditions

Reaction Steps

N,N-dimethyl-N′-(6-n-propyl-2-trifluoromethylimidazo[1,2-b]pyridazin-3-ylsulfonyl)formamidine (0.30 g, 0.83 mmol) was dissolved in dioxane (10.0 ml), and to the solution was added concentrated hydrochloric acid (5.0 ml) and stirred at 60° C. for 2 hours, 80° C. for 2 hours and 90° C. for 2 hours. The reaction mixture was concentrated under reduced pressure. To the residues was added water, and adjusted pH to 3 with aqueous 1N sodium hydroxide solution. The precipitated solid was collected by filtration, and washed with water to give the title compound as white crystals. The yield was 0.24 g (94.3%).

Provenance & Evidence