2'-Deoxyguanosine monohydrate → HCID 135960874, compound

HRID 969764Notes

Reaction equation

HRID 969764 reaction equation
[C:1]([C@@]1(N2C3N=C(N)NC(=O)C=3N=C2)O[C@H](CO)[C@@H](O)C1)(=[O:17])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].O.[C@@H:38]1([N:46]2[C:56]3[N:55]=[C:53]([NH2:54])[NH:52][C:50](=[O:51])[C:49]=3[N:48]=[CH:47]2)[O:45][C@H:42]([CH2:43][OH:44])[C@@H:40]([OH:41])[CH2:39]1>>[C:1]([O:41][C@@H:40]1[C@@H:42]([CH2:43][OH:44])[O:45][C@@H:38]([N:46]2[C:56]3[N:55]=[C:53]([NH2:54])[NH:52][C:50](=[O:51])[C:49]=3[N:48]=[CH:47]2)[CH2:39]1)(=[O:17])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16]

Participants

3

Reactant 2

HCID 1354457052'-Deoxyguanosine monohydrateHCID 136333583HCID 136333583, compound

Product 1

HCID 135960874HCID 135960874, compound

Conditions

Temperature
25 °C

Procedure

This compound was prepared using the procedure for Palmitoyl-2′-deoxyguanosine, substituting the appropriate amount of 5′-O-dimethoxytrityl-deoxyguanosine for 2′-deoxyguanosine monohydrate and deprotecting the 5′ hydroxyl group as follows: removing the dimethoxytrityl group by stirring in 80% aqueous acetic acid at 25 degrees C. for 1 hour, isolating the crude product by filtration, triturating the crude product for 1 hour in methanol, recovering the product by filtration and drying.

Workup

  1. customThis compound was prepared
  2. customremoving the dimethoxytrityl group

Sources & evidence

ORD record
ord-aefb2215b45943ebbc50bcf7e0ba0ba3
Source dataset
uspto-grants-2007_12
Patent number
US07307166B1

Reaction notes

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