2,6-Dichlorobenzothiazole → 2-(s)-(6-Chloro-benzothiazol-2-ylamino)-3-cyclohexyl-n-[2-(4-fluoro-phenylamino)-ethyl]-propionamide

HRID 969794Notes

Reaction equation

HRID 969794 reaction equation
Cl[C:2]1[S:3][C:4]2[CH:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:5]=2[N:6]=1.[CH2:12]1[CH2:17][CH2:16][CH:15]([CH2:18][C@H:19]([NH2:23])[C:20]([OH:22])=O)[CH2:14][CH2:13]1.Cl.Cl.[F:26][C:27]1[CH:32]=[CH:31][C:30]([NH:33][CH2:34][CH2:35][NH2:36])=[CH:29][CH:28]=1>>[Cl:11][C:9]1[CH:8]=[CH:7][C:5]2[N:6]=[C:2]([NH:23][C@@H:19]([CH2:18][CH:15]3[CH2:14][CH2:13][CH2:12][CH2:17][CH2:16]3)[C:20]([NH:36][CH2:35][CH2:34][NH:33][C:30]3[CH:31]=[CH:32][C:27]([F:26])=[CH:28][CH:29]=3)=[O:22])[S:3][C:4]=2[CH:10]=1

Participants

4

Reactant 3

HCID 771762,6-DichlorobenzothiazoleHCID 7124213-Cyclohexyl-L-alanineHCID 21082259n1-(4-Fluoro-phenyl)-ethane-1,2-diamine-2hcl

Product 1

HCID 113174972-(s)-(6-Chloro-benzothiazol-2-ylamino)-3-cyclohexyl-n-[2-(4-fluoro-phenylamino)-ethyl]-propionamide

Procedure

The title compound was prepared from 2,6-dichlorobenzothiazole, L-cyclohexylalanine and N1-(4-fluoro-phenyl)-ethane-1,2-diamine-2HCl using the procedure analogous to that described in example 2. 1H NMR (DMSO-d6, 400 MHz) δ 8.30 (d, 1H, J=8.0 Hz), 8.17 (t, 1H, J=5.6 Hz), 7.72 (d, 1H, J=2.4 Hz), 7.23 (d, 1H, J=8.4 Hz), 7.15 (dd, 1H, J=8.4 Hz, J=2.4 Hz), 6.84(m, 2H), 6.50(m, 2H), 4.40(m, 1H), 3.16(m, 2H), 2.97(m, 2H), 1.55(m, 7H), 1.30(m, 1H), 1.05(m, 3H), 0.83(m, 2H). HPLC-MS calcd. for C24H28ClFN4OS (M+H+)475.17, found 475.3.

Sources & evidence

ORD record
ord-aa1de46250534832936ea49544ab1f66
Source dataset
uspto-grants-2007_12
Patent number
US07307095B2

Reaction notes

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