反应详情

The crude isatin derivative from step (a) was refluxed in 60 mL of 10% potassium hydroxide in water for 4 hours. The reaction was then cooled to room temperature and filtered. The filtrate was acidified with a mixture of concentrated hydrochloric acid and ice until a dark precipitate separated out. The product was collected by filtration and dried under vacuum. Yield=0.32 g (10%).

1. filtrationfiltered
2. additionThe filtrate was acidified with a mixture of concentrated hydrochloric acid and ice until a dark precipitate
3. customseparated out
4. filtrationThe product was collected by filtration
5. customdried under vacuum