HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2-Pyridyl)piperazine → 1-(2-Pyridyl)-4-[3-(cyclohexanecarbonyl)-3-(phenyl)propyl]piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2-Pyridyl)piperazine | HCID 94459 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | 3-Cyclohexanecarbonyl-3-phenylpropionaldehyde | HCID 12051064 | — |
| Product | 1-(2-Pyridyl)-4-[3-(cyclohexanecarbonyl)-3-(phenyl)propyl]piperazine | HCID 15541844 | 78.3% |
Reaction Steps
Following the procedures described in the Example 1, Step C, the reaction of 3-cyclohexanecarbonyl-3-phenylpropionaldehyde (1.55 mmol) and 1-(2-pyridyl)piperazine (1.55 mmol) with sodium triacetoxyboranehydride (2.0 mmol) gave pure product 1-(2-pyridyl)-4-[3-(cyclohexanecarbonyl)-3-(phenyl)propyl]piperazine (475 mg) in 78% yield. The oxalate salt was prepared as described above. m.p.=185-187° C.; MS (m/e): 391 (M+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07309702B2 |
| Source dataset | uspto-grants-2007_12 |
| ORD ID | ord-6c5cfeb2e8e84a9d9fba4d0e6d93d467 |
| Source note | uspto-grants-2007_12 |