HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2-Methoxyphenyl)piperazine → 1-(2-Methoxyphenyl)-4-[3-(benzoyl)-3-(phenyl)butyl]piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2-Methoxyphenyl)piperazine | HCID 1346 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | 3-Benzoyl-3-phenylbutyraldehyde | HCID 12051066 | — |
| Product | 1-(2-Methoxyphenyl)-4-[3-(benzoyl)-3-(phenyl)butyl]piperazine | HCID 15524029 | 23.4% |
Reaction Steps
Following the procedures described in the Example 1, Step C, the reaction of 3-benzoyl-3-phenylbutyraldehyde (0.32 g) and 1-(2-methoxyphenyl)piperazine (0.23 g) with sodium triacetoxyboranehydride (0.33 g) gave pure product 1-(2-methoxyphenyl)-4-[3-(benzoyl)-3-(phenyl)butyl]piperazine (0.12 g). The oxalate salt was prepared as described above. m.p.=192-193° C.; MS (m/e): 428 (M+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07309702B2 |
| Source dataset | uspto-grants-2007_12 |
| ORD ID | ord-454c807d8ecf49938a11bf92c55568bf |
| Source note | uspto-grants-2007_12 |