Fumaric Acid → HCID 69432614, compound

Participants

Reaction Steps

The product of Example 2B (38 mg, 0.13 mmol) in ethyl acetate/methanol (3 mL, 10:1) was treated with fumaric acid (17 mg, 0.14 mmol) at ambient temperature overnight. The title compound was obtained as a solid (31 mg, yield, 55%): 1H NMR (MeOH-d4, 300 MHz) δ 1.82-2.21 (m, 3H), 2.30-2.42 (m, 1H), 2.55-2.62 (m, 1H), 3.35-3.50 (m, 5H), 3.75-3.82 (m, 1H), 4.95-5.02 (m, 1H), 6.65-6.72 (m, 3H), 6.88 (ddd, J=7.8, 2.7, 1.0 Hz, 1H), 6.92 (t, J=2.0 Hz, 1H), 7.01 (dt, J=8.8, 2.1 Hz, 2H), 7.14 (t, J=7.8 Hz, 1H), 7.53 (dt, J=8.8, 2.5 Hz, 2H) ppm. MS (DCl/NH3) m/z 295 (M+H)+. Anal. Calculated for C19H22N2O.1.19C4H4O4: C, 65.98; H, 6.24; N, 6.48. Found: C, 66.00; H, 6.00; N, 6.38.

Provenance & Evidence