(3-Amino-4-methylphenyl)boronic acid → HCID 11483659, compound

Participants

Reaction Steps

The product of Example 2A (165 mg, 0.5 mmol), was treated with 3-amino-4-methyl-phenylboronic acid (151 mg, 1 mmol) according to the procedure of Example 2B. The title product was purified by chromatography (SiO2, CH2Cl2:MeOH:NH3.H2O, 90:10:1, Rf. 0.25) as a solid (104 mg, yield, 68%). 1H NMR (MeOH-d4, 300 MHz) δ 1.45-1.58 (m, 1H), 1.64-1.89 (m, 2H), 2.00-2.13 (m, 1H), 2.15-2.23 (m, 4H), 2.76-3.02 (m, 5H), 3.30-3.40 (m, 1H), 4.51-4.59 (m, 1H), 6.6.84 (dd, J=7.8, 2.0 Hz, 1H), 6.90-6.97 (m, 3H), 7.02 (d, J=7.8 Hz, 1H), 7.47 (dt, J=8.8, 2.0 Hz, 2H) ppm. MS (DCl/NH3) m/z 309 (M+H)+.

Provenance & Evidence