Fumaric Acid → HCID 69431496, compound

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Reaction Steps

The product of Example 4A in ethyl acetate/ethanol (v.1:1, 4 mL) was treated with fumaric acid (40 mg, 0.34 mmol) at ambient temperature for 15 hours. The title compound was obtained as a solid (115 mg, yield, 77%). 1H NMR (MeOH-d4, 300 MHz) δ 1.79-2.16 (m, 3H), 2.18 (s, 3H), 2.24-2.39 (m, 1H), 2.46-2.54 (m, 1H), 3.20-3.42 (m, 5H), 3.71-3.81 (m, 1H), 6.68 (s, 2H), 6.83 (dd, J=7.8, 1.7 Hz, 1H), 6.94 (d, J=1.7 Hz, 1H), 6.97-7.06 (m, 3H), 7.51 (dt, J=8.5, 2.1 Hz, 2H) ppm. MS (Cl/NH3): m/z 309 (M+H)+. Anal. Calculated for C20H24N2O.C4H4O4: C, 67.91; H, 6.65; N, 6.60. Found: C, 67.62; H, 6.45; N, 6.43.

Provenance & Evidence