HCID 67070123, compound → HCID 11437857, compound

Participants

Reaction Steps

The product of Example 6E (384 mg, 1.18 mmol) in methanol (5 mL) was treated with Pd/C (Aldrich, wt. 10%, 50 mg) under H2 according to the procedure of Example 5C to provide the title compound (170 mg, yield, 49%). 1H NMR (MeOH-d4, 300 MHz) δ 1.44-1.58 (m, 1H), 1.63-1.89 (m, 2H), 1.99-2.13 (m, 1H), 2.15-2.23 (m, 1H), 2.72-3.04 (m, 5H), 3.29-3.39 (m, 1H), 4.48-4.56 (m, 1H), 6.76 (dt, J=8.8, 2.5 Hz, 2H), 6.91 (dt, J=8.8, 2.4 Hz, 2H), 7.31 (dt, J=8.5, 2.5 Hz, 2H), 7.43 (dt,J=9.2, 2.8 Hz, 2H) ppm. MS (DCl/NH3) m/z 295 (M+H)+.

Provenance & Evidence