Fumaric Acid → HCID 131726719, compound

Participants

Reaction Steps

The product of Example 16A (130 mg, 0.40 mmol) in ethyl acetate/ethanol (5 mL, 1:1) was treated with fumaric acid (47 mg, 0.4 mmol) at ambient temperature for 10 hours. The title compound was obtained as a solid (101 mg, yield, 63%). 1H NMR (MeOH-d4, 300 MHz) δ 1.74-2.11 (m, 3H), 2.18-2.34 (m, 1H), 2.43-2.51 (m, 1H), 3.00 (s, 6H), 3.08-3.37 (m, 5H), 3.65-3.79 (m, 1H), 5.24-5.33 (m, 1H), 6.67 (s, 1.2H), 6.84 (d, J=8.8 Hz, 2H), 7.80 (d, J=9.2 Hz, 2H), 8.23 (d, J=1.4 Hz, 1H), 8.50 (d, J=1.4 Hz, 1H) ppm. MS (DCl/NH3) m/z 325 (M+H)+. Anal. Calculated for C19H24N4O.0.6C4H4O4.0.3H2O: C, 64.34; H, 6.81; N, 14.03. Found: C, 64.45; H, 7.02; N, 13.86.

Provenance & Evidence