Potassium Carbonate → Tert-butyl 4-[2-(1-azabicyclo[2.2.2]oct-3-yloxy)pyrimidin-5-yl]phenylcarbamate

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Reaction Conditions

Reaction Steps

The product of Example 18A (283 mg, 1 mmol) in tetrahydrofuran (anhydrous, 10 mL) was treated with t-butyl [4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-carbamate (Frontier, 319 mg, 1 mmol), Pd2(dba)3 (Strem Chemicals, 24 mg, 0.025 mmol), (tBu3P)2Pd (Strem Chemicals, 26 mg, 0.05 mmol), K2CO3 (Aldrich, 276 mg 2 mmol) and heated at 60° C. under N2 for 15 hours. The resulting mixture was allowed to cool to room temperature, diluted with ethyl acetate (20 mL), and washed with brine (2×5 mL). The organic phase was concentrated and the title product was purified by chromatography (SiO2, CH2Cl2:MeOH:NH3.H2O, 90:10:1, Rf. 0.20) as a solid (340 mg, yield, 86%). 1H NMR (300 MHz, MeOH-d4) δ 1.48-1.63 (m, 10H), 1.65-1.91 (m, 2H), 2.02-2.16 (m, 1H), 2.22-2.30 (m, 1H), 2.75-3.05 (m, 5H), 3.36-3.48 (m, 1H), 5.13-5.21 (m, 1H), 7.54 (s, 4H), 8.78 (s, 2H) ppm. MS (DCl/NH3) m/z 397 (M+H)+.

Provenance & Evidence