HCID 86598009, compound → HCID 86598008, compound

Participants

Reaction Steps

A mixture of 8.7 g (21.7 mmol) of 2-(R)-trifluoroacetamido-4-oxo-4-(4-octylphenyl)butanoic acid (from Example 12, Step A) and 1.75 g of 10% Pd/C in 25 mL of HOAc was hydrogenated at 40 psi for 20 h. The mixture was filtered through a pad of Celite; the flask and pad were rinsed with EtOAc. Toluene was added to the filtrate and the filtrate was concentrated to afford 9.0 of the title compound which was used without further purification.

Provenance & Evidence